Windows Mobility Center is a fairly useful tool for those of us using Windows 7 or Vista on a laptop computer, but might not be for everybody, especially since it takes over the Win+X keyboard shortcut.
If you would rather disable Windows Mobility Center, all it takes is a single registry tweak.
Manual Registry Tweak
Open up regedit.exe through the start menu search box and then navigate to the following key, creating it if it doesn’t exist:
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Policies\MobilityCenter
Now create a new 32-bit DWORD entry in the right-hand pane called NoMobilityCenter and give it a value of 1.
Download Registry Tweak
The zip file contains both DisableMobility.reg and EnableMobility.reg files that will allow you to enable or disable the Mobility Center easily.
Download DisableMobility.zip Registry Hack